Analytical Data
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基因名
NPTXR
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简介
The NPTXR protein may mediate synaptic processes, suggesting its involvement in synaptic material uptake during remodeling or AMPA receptor clustering at specific excitatory synapses. These effects suggest that NPTXR dynamically regulates synaptic structure and function. NPTXR Protein, Human (HEK293, His) is the recombinant human-derived NPTXR protein, expressed by HEK293 , with N-His labeled tag.
- Application
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生物活性
Measured by the ability of the immobilized protein to support the adhesion of U87 human glioblastoma/astrocytoma cells. The ED50 for this effect is 0.1499 μg/mL, corresponding to a specific activity is 6.67×103units/mg. Measured by the ability of the immobilized protein to support the adhesion of U87 human glioblastoma/astrocytoma cells. The ED50 for this effect is 0.1499 μg/mL, corresponding to a specific activity is 6.67×103 units/mg.
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别名
Neuronal pentraxin receptor; NPTXR; NPR
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种属
Human
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表达系统
HEK293
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标签
N-10*His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O95502
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表达区间
A24-A500
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氨基酸序列
ASVPLAASPARALPGGADNASVASGAAASPGPQRSLSALHGAGGSAGPPALPGAPAASAHPLPPGPLFSRFLCTPLAAACPSGAQQGDAAGAAPGEREELLLLQSTAEQLRQTALQQEARIRADQDTIRELTGKLGRCESGLPRGLQGAGPRRDTMADGPWDSPALILELEDAVRALRDRIDRLEQELPARVNLSAAPAPVSAVPTGLHSKMDQLEGQLLAQVLALEKERVALSHSSRRQRQEVEKELDVLQGRVAELEHGSSAYSPPDAFKISIPIRNNYMYARVRKALPELYAFTACMWLRSRSSGTGQGTPFSYSVPGQANEIVLLEAGHEPMELLINDKVAQLPLSLKDNGWHHICIAWTTRDGLWSAYQDGELQGSGENLAAWHPIKPHGILILGQEQDTLGGRFDATQAFVGDIAQFNLWDHALTPAQVLGIANCTAPLLGNVLPWEDKLVEAFGGATKAAFDVCKGRAKA
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蛋白长度
Extracellular Domain
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分子量
55-75 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NPTXR, or Neuronal Pentraxin Receptor, is a protein that plays a critical role in the central nervous system, particularly in synaptic function and neuronal communication. Its involvement in neurodevelopmental processes and synaptic plasticity has garnered significant interest in the field of neuroscience. Recent studies have suggested that NPTXR may be implicated in various neuropsychiatric disorders, such as schizophrenia and autism spectrum disorders, making it a potential target for therapeutic intervention. The recombinant expression of NPTXR allows for detailed biochemical studies and functional assays, facilitating the exploration of its molecular mechanisms and interactions with other synaptic proteins. By producing NPTXR as a recombinant protein, researchers can investigate its structural properties, binding affinities, and functional role in neuronal signaling pathways. This research not only enhances our understanding of synaptic physiology but also opens avenues for developing novel strategies to address neurodevelopmental and neurodegenerative diseases. Moreover, recombinant NPTXR can serve as a valuable tool in drug screening and profiling, providing insights into how alterations in its function may influence neuronal health. Overall, the study of NPTXR and its recombinant protein form holds great promise for advancing our knowledge of neural connectivity and the underlying causes of various brain disorders.
