Analytical Data
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Gene name
BAG-2
- Application
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Alternative Names
rHuBAG2, His; BAG Family Molecular Chaperone Regulator 2; BAG-2; Bcl-2-Associated Athanogene 2; BAG2
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95816
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Expression Region
M1-N211
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AA Sequence
MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEVVNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSKTLQQNAESRFN
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Protein Length
Full Length
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Molecular Weight
25-30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BAG-2 (Bcl-2-associated athanogene 2) is a member of the BAG family of proteins, which are known to interact with heat shock proteins (HSPs) and play a critical role in various cellular processes, including apoptosis and protein folding. Research on BAG-2 has gained significant attention due to its involvement in cellular stress responses and its potential implications in cancer and neurodegenerative diseases. Elevated levels of BAG-2 have been observed in several types of cancer, suggesting that it may function as a prosurvival factor by inhibiting apoptosis. Additionally, BAG-2's role in modulating protein homeostasis highlights its importance in diseases characterized by protein misfolding. Studies have demonstrated that BAG-2 interacts with several targets, such as HSP70 and the tumor suppressor protein p53, thus influencing crucial signaling pathways. Understanding the functional mechanisms of BAG-2, including its interactions and regulatory effects, is essential for elucidating its role in health and disease. Recent advancements in recombinant protein technology have facilitated the production of BAG-2 for biochemical and biophysical studies, enabling researchers to dissect its function at the molecular level and potentially identify novel therapeutic targets for intervention in disease states where BAG-2 is implicated. This research is crucial for developing strategies to manipulate BAG-2 activity, providing insights into its dual roles in promoting cell survival and maintaining protein integrity, which may contribute to novel cancer therapies and neuroprotective strategies.
