Analytical Data
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Gene name
CIRBP
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简介
CIRBP is a cold-induced mRNA-binding protein that plays a key role in cellular responses to genotoxic stress, exerting a protective effect by stabilizing transcripts of genes critical for cell survival. As a translation activator, CIRBP appears to be critical for cold-induced inhibition of cell proliferation. CIRBP Protein, Human (His) is the recombinant human-derived CIRBP protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Cold-inducible RNA-binding protein A; XCIRP; cirbp-a; CIRP-1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14011-1
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Expression Region
M1-E172
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Protein Length
Full Length of Isoform-1
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Molecular Weight
23 kDa.
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CISD1, or CDGSH iron sulfur domain 1, is a protein that plays a crucial role in cellular functions, including iron-sulfur cluster biogenesis and mitochondrial homeostasis. Research surrounding CISD1 has gained attention due to its involvement in various pathological conditions, notably neurodegenerative diseases such as Alzheimer's and Parkinson's, where dysregulation of iron metabolism and mitochondrial dysfunction are implicated. Furthermore, CISD1 acts as a potential protective factor against oxidative stress, contributing to cell survival. This makes it a compelling target for understanding the underlying mechanisms of these diseases and exploring therapeutic interventions. Studies have shown that CISD1 is essential for maintaining mitochondrial integrity and regulating apoptosis, prompting investigations into its structure and function. Recombinant CISD1 proteins are being produced for detailed biochemical analyses, enabling researchers to elucidate the functional dynamics of this protein at the molecular level. As the scientific community seeks to identify potential biomarkers and therapeutic targets for neurodegeneration, CISD1 remains a significant focus, with studies aimed at delineating its role in cellular health and disease pathways. This background sets the stage for further exploration into the functional implications of CISD1 and the potential for developing interventions that leverage its protective properties in various diseases.
