Analytical Data
-
基因名
CIRBP
-
简介
CIRBP is a cold-induced mRNA-binding protein that plays a key role in cellular responses to genotoxic stress, exerting a protective effect by stabilizing transcripts of genes critical for cell survival. As a translation activator, CIRBP appears to be critical for cold-induced inhibition of cell proliferation. CIRBP Protein, Human (His) is the recombinant human-derived CIRBP protein, expressed by E. coli , with N-His labeled tag.
- Application
-
别名
Cold-inducible RNA-binding protein A; XCIRP; cirbp-a; CIRP-1
-
种属
Human
-
表达系统
E. coli
-
标签
N-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q14011-1
-
表达区间
M1-E172
-
蛋白长度
Full Length of Isoform-1
-
分子量
23 kDa.
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CISD1, or CDGSH iron sulfur domain 1, is a protein that plays a crucial role in cellular functions, including iron-sulfur cluster biogenesis and mitochondrial homeostasis. Research surrounding CISD1 has gained attention due to its involvement in various pathological conditions, notably neurodegenerative diseases such as Alzheimer's and Parkinson's, where dysregulation of iron metabolism and mitochondrial dysfunction are implicated. Furthermore, CISD1 acts as a potential protective factor against oxidative stress, contributing to cell survival. This makes it a compelling target for understanding the underlying mechanisms of these diseases and exploring therapeutic interventions. Studies have shown that CISD1 is essential for maintaining mitochondrial integrity and regulating apoptosis, prompting investigations into its structure and function. Recombinant CISD1 proteins are being produced for detailed biochemical analyses, enabling researchers to elucidate the functional dynamics of this protein at the molecular level. As the scientific community seeks to identify potential biomarkers and therapeutic targets for neurodegeneration, CISD1 remains a significant focus, with studies aimed at delineating its role in cellular health and disease pathways. This background sets the stage for further exploration into the functional implications of CISD1 and the potential for developing interventions that leverage its protective properties in various diseases.
