Analytical Data
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基因名
ATF1
- Application
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别名
rHuATF1, His; Cyclic AMP-dependent transcription factor ATF-1; cAMP-dependent transcription factor ATF-1; Activating transcription factor 1
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P18846
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表达区间
M1-V271
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氨基酸序列
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSVHHHHHH
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蛋白长度
Full Length
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分子量
34.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATF1 (Activating Transcription Factor 1) is a key transcription factor involved in various cellular processes, including stress response, apoptosis, and development. Research on ATF1 is significant due to its role in regulating gene expression in response to environmental stimuli, particularly in the context of cellular stress such as oxidative stress and hypoxia. ATF1 has been implicated in various diseases, including cancer, where its dysregulation can contribute to tumor progression and metastasis. Recent studies have highlighted its function in promoting cell survival and proliferation under adverse conditions, which has drawn attention to its potential as a therapeutic target. The expression and activity of ATF1 can be modulated by various signaling pathways, including the cAMP/PKA pathway, raising interest in understanding the mechanisms that govern its function. The investigation of recombinant ATF1 protein allows researchers to study its molecular properties, interaction with DNA, and binding to other proteins in vitro, providing insights into its biological roles and regulatory mechanisms. Additionally, recombinant ATF1 can serve as a tool for drug screening and development, particularly in identifying compounds that can modulate its activity for therapeutic benefits. Overall, the study of ATF1 and its recombinant protein form has the potential to advance our understanding of fundamental biological processes and their implications in disease pathology.
