Analytical Data
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基因名
NRXN3/Neurexin-3
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简介
Neurexin-3-beta is neuronal cell surface protein that is involved in cell recognition and cell adhesion. Neurexin-3-beta mediates intracellular signaling. NRXN3/Neurexin-3 Protein, Human (HEK293, His) is the recombinant human-derived NRXN3/Neurexin-3 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Neurexin-3-beta; Neurexin III-beta; NRXN3-CTF; NRXN3; KIAA0743
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q9HDB5-1
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表达区间
S36-L357
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氨基酸序列
SSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITL
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蛋白长度
Partial
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分子量
50-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Neurexin-3 (NRXN3) is a member of the neurexin family of synaptic cell adhesion molecules, which play a crucial role in the formation and maintenance of synapses in the central nervous system. These proteins are integral to neuronal communication, as they interact with a variety of neurotransmitter receptors and other synaptic proteins. Research into NRXN3 has gained momentum due to its association with various neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and attention-deficit hyperactivity disorder (ADHD). Genetic studies have identified specific variants in the NRXN3 gene that correlate with these conditions, suggesting its potential role in synaptic dysfunction and neurodevelopmental processes. Given its importance in synaptic biology, producing recombinant NRXN3 proteins is vital for elucidating its structure-function relationships and understanding its interactions with other synaptic components. This research provides key insights into the molecular mechanisms underlying synaptic transmission and may offer therapeutic targets for neurodevelopmental and psychiatric disorders. Advances in protein expression techniques and purification methods have enabled researchers to generate high-quality NRXN3 proteins to investigate their functional properties in vitro and in vivo, shedding light on the complex relationships between neurexins and neurological diseases. Thus, NRXN3 research is paramount for advancing our understanding of neuronal connectivity and the etiology of neuropsychiatric disorders.
