Analytical Data
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Gene name
ING5
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简介
The ING5 protein is a key component of the HBO1 complex and mediates H3K14ac and H4 acetylation. In the MOZ/MORF complex, it exhibits histone H3 acetyltransferase activity and may regulate DNA replication and act as a transcriptional coactivator. ING5 Protein, Human (His) is the recombinant human-derived ING5 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Inhibitor of growth protein 5; p28ING5; ING5
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q8WYH8-2
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Expression Region
E36-Q84
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Protein Length
Partial
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Molecular Weight
7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ING5 (Inhibitor of Growth Protein 5) is a member of the ING family, known for its role in regulating cell growth, apoptosis, and differentiation. This protein is characterized by its plant homeodomain (PHD) finger, which allows it to interact with chromatin and influence gene expression. Recent studies have highlighted the importance of ING5 in various biological processes, particularly its involvement in tumor suppressor activities, due to its ability to regulate cell cycle progression and apoptosis. Research has shown that ING5 is often downregulated or lost in various cancers, suggesting a critical role in maintaining cellular homeostasis and preventing tumorigenesis. Moreover, the interaction of ING5 with other proteins and its potential as a therapeutic target has garnered significant interest. Understanding the molecular mechanisms underlying ING5's functions could provide insights into novel cancer therapies and strategies for promoting cell cycle regulation. As such, ongoing research into ING5 and its role in cellular processes is vital for elucidating its contributions to cancer biology and potential implications for treatment strategies.
