Analytical Data
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Gene name
HMGN3
- Application
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Alternative Names
PNAS-24; PNAS-25; TRIP7; Thyroid Hormone Receptor Interactor 7; Thyroid receptor-interacting protein 7
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9DCB1
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Expression Region
Met1~Glu99
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Molecular Weight
15kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HMGN3, or High Mobility Group Nucleosome-Binding Domain 3, is a protein that plays a crucial role in chromatin structure and function, influencing gene expression by modulating the positioning and stability of nucleosomes. Research into HMGN3 has gained momentum due to its implications in various biological processes, including cellular proliferation, differentiation, and response to stress. Aberrant expression of HMGN3 has been linked to several diseases, including cancer, where it may function as an oncogene or tumor suppressor depending on the cellular context. Recombinant HMGN3 protein has become a valuable tool for studying its molecular mechanisms and interactions with DNA and histones, providing insights into chromatin dynamics and epigenetic regulation. Furthermore, the use of recombinant technology allows for the production of large quantities of HMGN3 for structural and functional analyses, paving the way for therapeutic applications. Understanding HMGN3's role in chromatin remodeling may offer new avenues for targeted therapies in diseases where chromatin dysregulation is a key feature. Overall, ongoing research on recombinant HMGN3 protein is expected to enhance our comprehension of its contributions to cellular homeostasis and its potential utility in clinical settings.
