Analytical Data
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Gene name
CSEN
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简介
CSEN is a calcium-dependent transcriptional repressor that binds to the DRE elements of genes such as PDYN and FOS. Its affinity to DNA is affected by calcium. The binding force is reduced in the presence of calcium and enhanced when combined with magnesium. CSEN Protein, Human (His) is the recombinant human-derived CSEN protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Calsenilin; A-type potassium channel modulatory protein 3; DREAM; KCNIP3; KCHIP3
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2W7-1
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Expression Region
M1-I256
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AA Sequence
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
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Protein Length
Full Length of Isoform-1
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Molecular Weight
29 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CSEN (Cystathionine β-synthase and associated proteins) is a key player in the metabolism of sulfur-containing amino acids, playing a crucial role in the biosynthesis of cysteine, a vital amino acid for numerous biological processes. Research on CSEN has gained prominence due to its involvement in various physiological functions, including cellular redox maintenance, antioxidant defense, and detoxification mechanisms. Dysregulation of CSEN activity has been linked to several diseases, including neurodegenerative disorders and metabolic syndromes, highlighting its potential as a therapeutic target. Recent advances in recombinant protein technology have facilitated the production and characterization of CSEN, enabling researchers to explore its structure-function relationships in greater depth. By generating recombinant CSEN proteins, scientists aim to elucidate its enzymatic mechanisms, identify essential regulatory domains, and assess its interactions with other cellular components. This research not only contributes to a deeper understanding of cysteine metabolism but also paves the way for developing novel therapeutic strategies aimed at modulating CSEN activity for disease intervention.
