Analytical Data
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基因名
COL6A3
- Application
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别名
COL6-A3; Collagen Alpha-3(VI)chain
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
J3QQ16
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表达区间
Asp2009~Leu2205
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分子量
26kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COL6A3, a gene part of the collagen VI family, encodes for one of the major components of this essential extracellular matrix protein. Collagen VI plays a critical role in maintaining the structural integrity of connective tissues and is involved in various biological processes, including cell adhesion, migration, and tissue repair. Abnormalities in COL6A3 have been linked to several pathologies, particularly muscle and connective tissue disorders, such as Ullrich congenital muscular dystrophy and Bethlem myopathy. These conditions highlight the importance of COL6A3 in muscle function and the integrity of the extracellular matrix. The recombinant expression of COL6A3 protein serves as a valuable tool for studying its biological functions and interactions in vitro and in vivo. Furthermore, understanding the structure-function relationships of COL6A3 can facilitate the development of potential therapeutic strategies, including gene therapy and protein replacement for patients affected by related disorders. Ongoing research aimed at elucidating the molecular mechanisms governing COL6A3 expression and functionality may lead to new insights into the treatment of muscular dystrophies and other connective tissue diseases. Therefore, the study of recombinant COL6A3 protein not only enhances our understanding of collagen biology but also opens avenues for innovative therapeutic approaches in regenerative medicine and tissue engineering.
