Analytical Data
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基因名
CAPG
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简介
Macrophage-capping protein (CAPG), a ubiquitous actin-binding protein, belongs to the gelsolin/villin superfamily and is associated with cell motility. CAPG is a Ca2+-sensitive protein and plays a role in macrophage function and is involved in the process of metastasis by promoting the invasiveness of tumor cells[1][2][3]. CAPG Protein, Human is the recombinant human-derived CAPG protein, expressed by E. coli , with tag free.
- Application
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别名
Macrophage-capping protein; Actin regulatory protein CAP-G; CAPG; AFCP; MCP
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
AAH14549
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表达区间
M1-K348
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氨基酸序列
MYTAIPQSGSPFPGSVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHNGPEEVSHLHLWIGQQSSRDEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLALAIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKPALKEGNPEEDLTADKANAQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVAEGFISRMQYAPNTQVEILPQGRESPIFKQFFKDWK
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蛋白长度
Full Length
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分子量
40 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CAPG, a member of the gelsolin superfamily of actin-binding proteins, plays a crucial role in regulating actin dynamics, which are vital for various cellular processes such as motility, cytokinesis, and cell shape maintenance. The study of CAPG has gained prominence due to its involvement in critical biological functions and its potential link to various diseases, including cancer and developmental disorders. Aberrant expression of CAPG has been associated with tumor progression and metastasis, making it an attractive target for therapeutic interventions. Recent advances in recombinant protein technology have enabled the production of CAPG in controlled environments, allowing researchers to investigate its structure-function relationships and interaction with actin filaments in detail. Understanding the molecular mechanisms by which CAPG modulates actin dynamics can provide insights into its role in health and disease, paving the way for potential applications in drug design and therapeutic strategies to combat cancer and other actin-related disorders. This research not only deepens our comprehension of CAPG's biological significance but also contributes to the broader field of cell biology by elucidating the intricate networks of actin regulation in cellular contexts.
