Analytical Data
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基因名
ATOX1
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简介
ATOX1 Protein plays a crucial role in cellular copper transport, binding to and delivering cytosolic copper to copper ATPase proteins. This process is integral to cellular antioxidant defense mechanisms. ATOX1 functions as a homodimer, supported by research findings. It interacts with ATP7B and ATP7A. In its dimer form, ATOX1 interacts with SLC31A1, contributing to its stability and controlling intracellular Cu(I) levels. ATOX1 Protein, Human (His) is the recombinant human-derived ATOX1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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别名
Copper transport protein ATOX1; Metal transport protein ATX1; HAH1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
O00244
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表达区间
M1-E68
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蛋白长度
Full Length
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分子量
9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATOX1, a member of the copper chaperone family, plays a pivotal role in cellular copper homeostasis by mediating the transport of copper ions to target proteins, particularly in the context of copper delivery to the enzyme cytochrome c oxidase. As a highly conserved protein, ATOX1 is expressed in various tissues and has been identified as a key player in oxidative stress responses and cellular signaling pathways. Recent studies have highlighted its involvement in cancer biology, specifically in tumor progression and metastasis, due to its ability to regulate copper-dependent processes. The recombinant expression of ATOX1 allows for detailed investigations into its biochemical properties, interactions, and regulatory mechanisms. By producing ATOX1 as a recombinant protein, researchers can elucidate its function and potential as a therapeutic target in diseases characterized by copper dysregulation, including neurodegenerative disorders and cancer. Understanding the structure-function relationship of ATOX1 through recombinant techniques may pave the way for innovative strategies to modulate its activity, thereby offering insights into novel therapeutic avenues that leverage copper's role in cellular metabolism.
