Analytical Data
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Gene name
WWP1
- Application
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Alternative Names
WW Domain Containing E3 Ubiquitin Protein Ligase 1; WWP1; Atrophin-1 Interacting Protein 5; AIP5; Tiul1
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Species
Human
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Source
Baculovirus
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Tag
N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0M0-1
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Expression Region
A2-E922
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Protein Length
Partial
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Molecular Weight
110-120 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WWP1 is an E3 ubiquitin ligase that plays a crucial role in cellular regulation by tagging proteins for degradation via the ubiquitin-proteasome system. Research has shown that WWP1 is involved in various biological processes, including signal transduction, cell proliferation, and apoptosis. Its dysregulation has been implicated in several diseases, particularly cancers, where it may influence tumor growth and metastasis by modulating the degradation of key regulatory proteins. The study of WWP1 recombinant protein offers insights into its structural and functional properties, enabling a better understanding of its mechanisms of action. Additionally, functional assays using WWP1 can help elucidate its role in various signaling pathways and its potential as a therapeutic target. By harnessing recombinant DNA technology, researchers aim to produce WWP1 in sufficient quantities for detailed biochemical and biophysical studies, paving the way for innovative treatments that might restore normal cellular function in diseases associated with WWP1 dysregulation. Understanding WWP1's interactions with its substrates and other signaling molecules may provide important clues for developing targeted therapies in oncology and beyond.
