Analytical Data
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基因名
FGFR-2
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简介
The FGFR-2 α IIIc protein is a tyrosine protein kinase receptor for fibroblast growth factor and is critical for embryonic development, regulating proliferation, differentiation, and apoptosis. Its importance is evident in embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis, and skin development. FGFR-2 Protein, Human (Biotinylated, sf9, Avi) is the recombinant human-derived FGFR-2, expressed by Sf9 insect cells , with Avi labeled tag.
- Application
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别名
Fibroblast growth factor receptor 2; FGFR-2; KSAM; KGFR; CD332; BEK
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种属
Human
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表达系统
Baculovirus
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标签
Avi
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P21802-1
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表达区间
D456-E768
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast Growth Factor Receptor 2 (FGFR-2) is a vital member of the FGFR family, known for its critical roles in cell proliferation, differentiation, and survival. It is particularly implicated in various physiological processes, including angiogenesis and wound healing. Dysregulation or mutations in FGFR-2 are associated with several diseases, including certain cancers and congenital disorders such as Apert syndrome. The study of FGFR-2 has gained prominence due to its potential as a therapeutic target. Researchers have been focusing on developing recombinant FGFR-2 proteins to understand its structure-function relationships and the mechanisms underlying its activation. Such recombinant proteins can be used in a variety of applications, such as drug screening, the development of targeted therapies, and investigating FGFR-2's role in cell signaling pathways. Furthermore, the generation of FGFR-2 variants and their interactions with specific ligands can provide insights into the receptor's ligand-binding dynamics and subsequent downstream signaling effects. As FGFR-2 continues to be a focal point in cancer biology and regenerative medicine, the development and characterization of its recombinant proteins could lead to novel therapeutic strategies that exploit this receptor's essential functions.
