Analytical Data
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Gene name
CDK10-CCNM
- Application
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Species
Human
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Source
Baculovirus
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Tag
N-GST;N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15131-1 (M1-P360)&Q8N1B3-1
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Expression Region
Q15131-1 (M1-P360)&Q8N1B3-1 (M1-P248)
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK10 (Cyclin-Dependent Kinase 10) is a key regulatory enzyme involved in various cellular processes, particularly in the cell cycle and transcriptional regulation. It functions by phosphorylating Serine 2 of the C-terminal domain of RNA polymerase II, thus playing a crucial role in the transcriptional elongation of protein-coding genes. CCNM (Cyclin M) is a cyclin that partners with CDK10, influencing its activity and specificity. The CDK10-CCNM complex has gained attention in recent years due to its involvement in crucial biological pathways, including cell proliferation and differentiation, which are vital for normal development and tissue homeostasis. Dysregulation of this complex has been implicated in various diseases, particularly cancers, where aberrant cell cycle control and transcriptional misregulation may occur. Understanding the structural and functional characteristics of the CDK10-CCNM recombinant protein is essential for elucidating their mechanism of action and potential role in pathological conditions. By studying this complex, researchers hope to unveil novel therapeutic targets that could lead to innovative treatment strategies for diseases linked to CDK10-CCNM dysregulation. This research not only contributes to the fundamental understanding of cell cycle regulation but also expands the frontier of cancer biology and potential regenerative medicine applications.
