Analytical Data
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Gene name
ERBB4
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简介
HER4 is an important tyrosine protein kinase receptor for members of the neuregulin and EGF families that directs heart, central nervous system, and mammary gland development. It is critical for myocardial differentiation, postnatal cardiomyocyte proliferation, neural crest cell migration, axon guidance, and mammary gland function. ERBB4 Protein, Human (sf9, GST) is the recombinant human-derived ERBB4, expressed by Sf9 insect cells, with GST labeled tag. The total length of ERBB4 Protein, Human (sf9, GST) is 633 a.a..
- Application
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Alternative Names
ERBB4; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Her4; c-erbB-4
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15303-1
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Expression Region
R676-V1308
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Protein Length
Cytoplasmic Domain
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERBB4, part of the epidermal growth factor receptor (EGFR) family, plays a pivotal role in various cellular processes, including proliferation, differentiation, and survival. Research has shown that ERBB4 is involved in numerous physiological and pathological conditions, particularly in neurological development and cancer. As a receptor tyrosine kinase, it can be activated by neuregulins and other ligands, leading to diverse downstream signaling pathways. Its unique splicing variants contribute to its functional diversity, with some isoforms promoting cell growth and others involved in apoptosis. Given its significant role in breast cancer and other malignancies, ERBB4 has emerged as a potential therapeutic target. Studies have focused on the characterization of ERBB4 recombinant proteins to better understand its molecular mechanisms and interactions. These recombinant proteins facilitate the exploration of ERBB4's structure-function relationships, enhancing our understanding of its role in tumor biology and offering insights into new treatment strategies. Researchers are particularly interested in designing inhibitors that can selectively block ERBB4 signaling to combat cancers where its dysregulation is prominent. Thus, ERBB4 recombinant protein studies form a crucial foundation for developing innovative targeted therapies and unraveling the complexities of receptor signaling in various diseases.
