Analytical Data
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Gene name
MST3/STK24
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简介
MST3/STK24 is a serine/threonine protein kinase that induces apoptosis in response to stress and caspase activation. It mediates oxidative stress-induced cell death by regulating the phosphorylation of JNK1-JNK2 and p38 during oxidative stress. MST3/STK24 Protein, Human (sf9, GST) is the recombinant human-derived MST3/STK24, expressed by Sf9 insect cells, with GST labeled tag.
- Application
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Alternative Names
STK24; serine/threonine kinase 24; MST3; STK3; MST3B; STE20; HEL-S-95
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6E0-1
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Expression Region
M1-H443
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MST3 (Mammalian Ste20-like protein kinase 3) and STK24 (Serine/Threonine Kinase 24) proteins belong to the Ste20 family of kinases, which are pivotal in regulating various cellular processes such as apoptosis, cell proliferation, and migration. Research into the MST3 and STK24 proteins has gained momentum due to their implicated roles in several diseases, including cancer, where they may influence tumorigenesis and metastasis. These kinases are known to participate in the Hippo signaling pathway, a key regulator of organ size and tissue homeostasis. The dysregulation of this pathway has been linked to excessive cell growth and inhibition of apoptosis. Furthermore, MST3 and STK24 interact with various downstream targets, modulating signal transduction pathways that affect cell fate and behavior. Understanding the functional mechanisms of MST3 and STK24 through recombinant protein studies can offer insights into their regulatory roles and potential as therapeutic targets. Furthermore, the structural characterization and activity analysis of these kinases will help elucidate their molecular interactions and pathways involved in disease progression. Therefore, the study of MST3/STK24 recombinant proteins is crucial for advancing our knowledge of cellular signaling and the development of novel strategies for intervention in disease-related processes.
