Analytical Data
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基因名
MST3/STK24
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简介
MST3/STK24 is a serine/threonine protein kinase that induces apoptosis in response to stress and caspase activation. It mediates oxidative stress-induced cell death by regulating the phosphorylation of JNK1-JNK2 and p38 during oxidative stress. MST3/STK24 Protein, Human (sf9, GST) is the recombinant human-derived MST3/STK24, expressed by Sf9 insect cells, with GST labeled tag.
- Application
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别名
STK24; serine/threonine kinase 24; MST3; STK3; MST3B; STE20; HEL-S-95
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种属
Human
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表达系统
Baculovirus
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标签
GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6E0-1
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表达区间
M1-H443
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蛋白长度
Full Length of Isoform-1
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MST3 (Mammalian Ste20-like protein kinase 3) and STK24 (Serine/Threonine Kinase 24) proteins belong to the Ste20 family of kinases, which are pivotal in regulating various cellular processes such as apoptosis, cell proliferation, and migration. Research into the MST3 and STK24 proteins has gained momentum due to their implicated roles in several diseases, including cancer, where they may influence tumorigenesis and metastasis. These kinases are known to participate in the Hippo signaling pathway, a key regulator of organ size and tissue homeostasis. The dysregulation of this pathway has been linked to excessive cell growth and inhibition of apoptosis. Furthermore, MST3 and STK24 interact with various downstream targets, modulating signal transduction pathways that affect cell fate and behavior. Understanding the functional mechanisms of MST3 and STK24 through recombinant protein studies can offer insights into their regulatory roles and potential as therapeutic targets. Furthermore, the structural characterization and activity analysis of these kinases will help elucidate their molecular interactions and pathways involved in disease progression. Therefore, the study of MST3/STK24 recombinant proteins is crucial for advancing our knowledge of cellular signaling and the development of novel strategies for intervention in disease-related processes.
