Recombinant Human Neurofascin Protein，His

Neurofascin is a member of the immunoglobulin superfamily and is primarily expressed in the nervous system, playing critical roles in neuronal development and myelination. It exists in two primary isoforms—Neurofascin 155 and Neurofascin 186—which are localized at different sites in the neuron: Neurofascin 155 is found in the nodes of Ranvier and is crucial for the proper conduction of action potentials, while Neurofascin 186 is associated with myelinating glial cells and is involved in the formation of axoglial junctions. Given its importance in neural function and the pathophysiology of neurodegenerative diseases, including Multiple Sclerosis and Charcot-Marie-Tooth disease, research on Neurofascin recombinant proteins has gained significance. These recombinant proteins are utilized to study their structural properties, binding interactions, and functional roles in cell adhesion and signaling pathways. The study of Neurofascin not only enhances our understanding of neuronal communication and myelination but also opens avenues for potential therapeutic strategies targeting demyelinating diseases. As such, the development and characterization of Neurofascin recombinant proteins are pivotal for both basic neuroscience research and clinical applications.