Analytical Data
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基因名
PAX8
- Application
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
Q06710
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表达区间
Met1~Pro143
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分子量
19kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAX8 is a member of the paired box (PAX) family of transcription factors, playing a critical role in organ development, particularly in the thyroid, kidney, and reproductive systems. The research surrounding PAX8 has gained significant attention due to its implications in various diseases, particularly thyroid cancer and developmental disorders. Abnormal expression of PAX8 is frequently observed in thyroid tumors, making it a potential biomarker for diagnosis and a target for therapeutic strategies. Additionally, PAX8 is essential for the proper formation of the thyroid gland and kidneys, signaling its importance in embryonic development. Researchers have been investigating PAX8's regulatory mechanisms, target genes, and interactions with other signaling pathways to better understand its role in tumorigenesis and organogenesis. Through the study of PAX8 recombinant proteins, scientists aim to unravel its functional dynamics, providing insights that could lead to novel approaches for manipulating its activity in both health and disease. Understanding the structural and functional aspects of PAX8 will enhance our knowledge of its contribution to cellular processes and its potential as a therapeutic target in conditions where its normal function is disrupted.
