Analytical Data
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Gene name
PAX8
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简介
PAX8 protein, a crucial transcription factor, is essential for thyroid-specific gene expression, maintaining the functional differentiation of thyroid cells. It plays a pivotal role in regulating the thyroid-specific gene profile, contributing to specialized thyroid cell function. PAX8 also interacts with WWTR1, indicating a potential partnership in modulating gene expression and cellular processes in thyroid cells. PAX8 Protein, Human (His) is the recombinant human-derived PAX8 protein, expressed by E. coli , with C-His labeled tag.
- Application
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Alternative Names
Paired box protein Pax-8; PAX8
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q06710
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Expression Region
P2-S146
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Protein Length
Partial
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Molecular Weight
17 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAX8 is a member of the paired box (PAX) family of transcription factors, playing a critical role in organ development, particularly in the thyroid, kidney, and reproductive systems. The research surrounding PAX8 has gained significant attention due to its implications in various diseases, particularly thyroid cancer and developmental disorders. Abnormal expression of PAX8 is frequently observed in thyroid tumors, making it a potential biomarker for diagnosis and a target for therapeutic strategies. Additionally, PAX8 is essential for the proper formation of the thyroid gland and kidneys, signaling its importance in embryonic development. Researchers have been investigating PAX8's regulatory mechanisms, target genes, and interactions with other signaling pathways to better understand its role in tumorigenesis and organogenesis. Through the study of PAX8 recombinant proteins, scientists aim to unravel its functional dynamics, providing insights that could lead to novel approaches for manipulating its activity in both health and disease. Understanding the structural and functional aspects of PAX8 will enhance our knowledge of its contribution to cellular processes and its potential as a therapeutic target in conditions where its normal function is disrupted.
