Analytical Data
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基因名
ZAP70
- Application
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种属
Human
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表达系统
Baculovirus
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标签
His;GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P43403-1
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表达区间
P2-A619
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZAP70, or Zeta-chain-associated protein kinase 70, is a crucial enzyme involved in T-cell receptor (TCR) signaling. It plays a significant role in the activation and proliferation of T cells, which are essential components of the adaptive immune system. Dysregulation of ZAP70 has been implicated in various immune disorders, including autoimmune diseases and cancers, highlighting its importance as a potential therapeutic target. Research has shown that ZAP70 functions primarily in phosphorylating substrates that are pivotal in the TCR signaling cascade, thereby facilitating T cell activation and promoting an effective immune response. Additionally, ZAP70 mutations can lead to immunodeficiencies, further underscoring its significance in immune system functionality. The development of recombinant ZAP70 proteins has garnered attention for their potential in studying T cell biology and developing novel immunotherapeutic strategies. These recombinant proteins allow researchers to explore ZAP70's structure-function relationships and its role in T cell signaling pathways, providing insight into how T cells respond to pathogens and tumors. As a result, ZAP70 remains a focal point of immunological research, aiming to develop targeted therapies that can enhance T cell responses in immunotherapy or modulate inappropriate immune activation in autoimmune diseases.
