Analytical Data
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基因名
MOG
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简介
MOG Protein potentially finalizes and maintains the myelin sheath, contributing to cell-cell communication.It acts as a homophilic cell adhesion molecule, mediating cellular interactions through homodimerization, indicating its involvement in establishing connections within myelin-related processes.MOG Protein, Mouse (His) is the recombinant mouse-derived MOG protein, expressed by E.coli , with C-His labeled tag.
- Application
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别名
Myelin-oligodendrocyte glycoprotein; Mog; MOGIG2
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种属
Mouse
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q61885
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表达区间
G29-T156
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蛋白长度
Extracellular Domain
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of Myelin Oligodendrocyte Glycoprotein (MOG) recombinant proteins has gained significant attention in the field of neuroimmunology, primarily due to their pivotal role in demyelinating diseases such as multiple sclerosis (MS). MOG is a crucial component of the myelin sheath formed by oligodendrocytes in the central nervous system (CNS), and it serves as a target for autoimmune responses in various demyelinating conditions. Research has focused on the structural and functional characterization of MOG, and the development of recombinant forms has provided valuable tools for both diagnostic and therapeutic applications. By generating MOG recombinant proteins, scientists can study the specific immune responses they elicit, paving the way for potential interventions that could modulate these responses. Furthermore, these proteins are instrumental in understanding the mechanisms of myelin repair and regeneration, as well as aiding in the identification of biomarkers for early disease diagnosis. Recent advancements in recombinant DNA technology have enabled the production of high-purity MOG proteins, facilitating innovative experimental designs, including in vitro assays and animal models that simulate autoimmune responses. Overall, the exploration of MOG recombinant proteins represents a promising avenue for advancing our understanding of CNS autoimmune diseases and developing targeted therapies that could mitigate the progression of demyelination and promote neurological recovery.
