Analytical Data
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基因名
IL-30
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简介
IL-30/IL-27A proteins cooperate with EBI3 to form IL-27, a key cytokine in innate immunity with pro- and anti-inflammatory properties. IL-27 regulates T helper cell development, inhibits T cell proliferation and affects various immune cells, affects CD4 T helper cell differentiation and promotes rapid clonal expansion. Animal-Free IL-30/IL-27A Protein, Human (His) is the recombinant human-derived animal-FreeIL-30/IL-27A protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.
- Application
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别名
Interleukin-27 subunit beta; IL-27B; Ebi3; Interleukin-27 subunit alpha; IL-27A; p28
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
> 90% as determined by SDS-PAGE.
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蛋白编号
Q8NEV9
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表达区间
F29-P243
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氨基酸序列
MFPRPPGRPQLSLQELRREFTVSLHLARKLLSEVRGQAHRFAESHLPGVNLYLLPLGEQLPDVSLTFQAWRRLSDPERLCFISTTLQPFHALLGGLGTQGRWTNMERMQLWAMRLDLRDLQRHLRFQVLAAGFNLPEEEEEEEEEEEEERKGLLPGALGSALQGPAQVSWPQLLSTYRLLHSLELVLSRAVRELLLLSKAGHSVWPLGFPTLSPQP
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蛋白长度
Full Length of Mature Protein
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分子量
28 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Interleukin-30 (IL-30), a recently identified member of the interleukin-6 cytokine family, plays a critical role in the immune response and has gained attention for its potential therapeutic applications. Research indicates that IL-30 is predominantly expressed in activated T cells and has been implicated in various inflammatory and autoimmune diseases. Its unique ability to regulate the activity of immune cells and modulate inflammatory responses makes it a candidate for further exploration in disease contexts, particularly those characterized by excessive inflammation or dysregulated immune function. Additionally, recombinant IL-30 protein has been produced to facilitate detailed studies regarding its biological functions and signaling pathways. Understanding the mechanisms of IL-30's action could provide insights into novel treatment strategies for conditions such as rheumatoid arthritis, multiple sclerosis, and other immune-mediated disorders. Furthermore, the development of IL-30-based therapies may enhance the efficacy of existing treatments and improve patient outcomes in chronic inflammatory diseases. As research progresses, characterization of IL-30’s interactions with other cytokines and its role in immune cell differentiation remains a focal point, offering avenues for targeted interventions and biomarker discovery. Overall, the investigation of IL-30 and its recombinant form holds promise in the realm of immunotherapy and precision medicine, underscoring the importance of cytokine biology in managing complex diseases.
