Analytical Data
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Gene name
p38 alpha/MAPK14
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简介
The p38 delta/MAPK13 protein is an important serine/threonine kinase in the MAP kinase pathway. It coordinates cellular responses to stimuli such as cytokines or stress and directly activates the transcription factors ELK1 and ATF2. In this cascade, p38 MAPK (including MAPK13) each phosphorylates approximately 200 to 300 substrates. p38 delta/MAPK13 Protein, Human (sf9, GST) is the recombinant human-derived p38 delta/MAPK13 protein, expressed by Sf9 insect cells , with N-GST labeled tag.
- Application
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Alternative Names
Mitogen-activated protein kinase 13; MAPK 13; PRKM13; SAPK4
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Species
Human
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Source
Baculovirus
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Tag
N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15264-1
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Expression Region
M1-L365
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Protein Length
Full Length of Isoform-1
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Molecular Weight
63.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
p38 alpha/MAPK14 is a crucial member of the mitogen-activated protein kinase (MAPK) family, playing a significant role in cellular responses to stress, inflammation, and cell differentiation. It is activated by various extracellular stimuli, including pro-inflammatory cytokines and stress signals, leading to the phosphorylation of numerous downstream targets involved in gene expression, cell cycle regulation, and apoptosis. Given its involvement in critical physiological and pathological processes, such as cancer, neurodegenerative diseases, and autoimmune disorders, p38 alpha has emerged as a promising therapeutic target. Research into recombinant p38 alpha/MAPK14 proteins has facilitated the elucidation of its structural and functional properties, enabling the development of specific inhibitors that could modulate its activity in disease contexts. Understanding the signaling pathways and interactions mediated by p38 alpha is essential for designing novel treatments aimed at harnessing its regulatory functions in cellular processes. Additionally, recombinant proteins provide a valuable tool for studying the precise mechanisms of p38 alpha activation and its role in different biological systems, laying the groundwork for future therapeutic interventions.
