Analytical Data
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Gene name
MR1-B2M Complex
- Application
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Alternative Names
MR1 & B2M; Major histocompatibility complex class I-related protein 1; MR1; MHC class I-related protein 1; Class I histocompatibility antigen-like protein; MR1
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Species
Human
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Source
HEK293
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Tag
C-Avi;C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q95460-1 (R23-M302)& P61769
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Expression Region
Q95460-1 (R23-M302)& P61769 (I21-M119)
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Molecular Weight
42-45 kDa and 13 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The MR1-B2M complex is a pivotal component of the immune system, particularly in the presentation of metabolites to mucosal-associated invariant T (MAIT) cells. Research into this complex has gained traction due to its crucial role in bridging innate and adaptive immunity. MR1, a non-classical major histocompatibility complex (MHC) class I molecule, is responsible for displaying riboflavin metabolites derived from various microbial and host sources. B2M (Beta-2-microglobulin) is essential for the stable expression of MR1 on the cell surface. The interaction between MR1 and B2M facilitates the recognition of antigens by MAIT cells, leading to a potent immune response against infected or transformed cells. Understanding the structure and dynamics of the MR1-B2M complex is vital for elucidating its mechanism of action and its implications in disease contexts such as bacterial infections, autoimmune disorders, and cancer. Consequently, advances in recombinant protein technology have allowed researchers to produce and study the MR1-B2M complex in vitro, enabling the development of potential therapeutic strategies aimed at modulating MAIT cell responses. Such studies may provide insights into novel immunotherapies and vaccines, enhancing our comprehension of immune surveillance and tolerance in various clinical settings.
