Recombinant Human HLA-E*01:03&B2M&CMV UL40(VMAPRTLLL) Monomer Protein (HEK293)，Avi & His

HLA-E*01:03 is a non-classical major histocompatibility complex (MHC) Class I molecule that plays a crucial role in immune regulation and response, particularly in the context of viral infections. It is known to present the peptide UL40 derived from cytomegalovirus (CMV), specifically the sequence VMAPRTLLL, to immune cells, which helps in the modulation of natural killer (NK) cell activities. Due to its unique ability to interact with both NK cell receptors and T cells, HLA-E is an important target for studying immune evasion mechanisms employed by viruses. Understanding the structure and function of HLA-E*01:03 in conjunction with the B2M (beta-2-microglobulin) protein, which is essential for the stability and surface expression of MHC Class I molecules, can provide insights into the interplay between the host immune system and viral pathogens. The investigation of recombinant monomeric forms of HLA-E*01:03 in complex with B2M and the CMV UL40 peptide enables researchers to explore binding affinities, structural conformations, and potential therapeutic implications in vaccine design or immunotherapy strategies aimed at enhancing immune responses against CMV and other viral diseases. This research not only advances the understanding of the human immune system but also has significant implications for developing novel therapeutic approaches to combat viral infections and regulate immune tolerance in various clinical scenarios.