Analytical Data
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基因名
Apolipoprotein M/APOM
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简介
Apolipoprotein M (APOM) is likely involved in lipid transport, binding various molecules, including sphingosine-1-phosphate, myristic acid, palmitic acid, stearic acid, retinol, all-trans-retinoic acid, and 9-cis-retinoic acid. Interacting with LRP2, APOM undergoes renal uptake facilitated by LRP2, followed by lysosomal degradation. This suggests APOM's role in mediating dynamic lipid and retinoid metabolism processes within the body. Apolipoprotein M/APOM Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Apolipoprotein M/APOM, expressed by P. pastoris , with N-His labeled tag.
- Application
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别名
Apom; Ng20Apolipoprotein M; Apo-M
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种属
Mouse
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表达系统
P. pastoris
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Z1R3
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表达区间
M1-K190
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氨基酸序列
MFHQVWAALLSLYGLLFNSMNQCPEHSQLTALGMDDTETPEPHLGLWYFIAGAASTTEELATFDPVDNIVFNMAAGSAPRQLQLRATIRTKSGVCVPRKWTYRLTEGKGNMELRTEGRPDMKTDLFSSSCPGGIMLKETGQGYQRFLLYNRSPHPPEKCVEEFQSLTSCLDFKAFLVTPRNQEACPLSSK
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蛋白长度
Full Length
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分子量
30.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Apolipoprotein M (APOM) is a lipid-binding protein that plays a crucial role in lipid metabolism and cardiovascular health. It is primarily associated with high-density lipoprotein (HDL) and is involved in the transport of lipids, particularly sphingosine-1-phosphate (S1P), which is essential for various biological functions, including cell signaling and immune response. Recent studies have highlighted APOM's potential as a biomarker for cardiovascular diseases and metabolic disorders. Moreover, its involvement in the modulation of inflammation and endothelial function suggests that APOM could be a therapeutic target for various conditions. The recombinant production of APOM offers opportunities to further investigate its biological functions and therapeutic potential. By utilizing genetic engineering techniques, researchers can produce large quantities of pure and active APOM protein, allowing for in-depth characterization and high-throughput screening of its interactions with lipids and receptors. Understanding the structure-function relationship of APOM through recombinant technology may elucidate its role in lipid metabolism and its impact on cardiovascular health, paving the way for innovative therapeutic strategies. As such, the study of recombinant APOM is not only relevant for its foundational insights into lipid biology but also holds promise for its applications in diagnostics and therapeutics.
