Analytical Data
-
Gene name
CSNK1A1
-
简介
Casein kinase I α is a member of casein kinases that exhibits a preference for phosphorylation of acidic proteins such as casein. It phosphorylates many substrates, including CTNNB1 at "Ser-45" involved in Wnt signaling. CSNK1A1 Protein, Human (sf9, His, Strep) is the recombinant human-derived CSNK1A1, expressed by Sf9 insect cells, with Strep, His labeled tag. The total length of CSNK1A1 Protein, Human (sf9, His, Strep) is 336 a.a..
- Application
-
Alternative Names
CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975
-
Species
Human
-
Source
Baculovirus
-
Tag
Strep;His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P48729-1
-
Expression Region
A2-F337
-
Protein Length
Full Length of Isoform-1 Mature Protein
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CSNK1A1, or Casein Kinase 1 Alpha 1, is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including cell signaling, circadian rhythm regulation, and cellular proliferation. Its involvement in the Wnt signaling pathway further underscores its significance in developmental biology and cancer research, as aberrant signaling can lead to oncogenesis. The study of recombinant CSNK1A1 protein has gained traction due to its potential as a therapeutic target and biomarker in cancer treatment. Advances in recombinant DNA technology have enabled the production of CSNK1A1, allowing researchers to investigate its biochemical properties and functional mechanisms. By expressing and purifying this protein, scientists can explore its enzymatic activities, substrate interactions, and regulatory mechanisms. Understanding the role of CSNK1A1 at the molecular level could provide insights into its contribution to disease processes and facilitate the development of novel therapeutic strategies. Overall, the ongoing research into recombinant CSNK1A1 is essential for elucidating its biological functions and therapeutic potential in oncology and beyond.
