Analytical Data
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Gene name
MAPKAPK2
- Application
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Alternative Names
MK2; MAPK-activated protein kinase 2; Mitogen Activated Protein Kinase Activated Protein Kinase 2
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P49137
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Expression Region
Glu139~Tyr367
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Molecular Weight
30kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MAPKAPK2 (Mitogen-Activated Protein Kinase-Activated Protein Kinase 2) is a serine/threonine kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and stress responses. It is activated by the MAPK pathway, which is known to be involved in the cellular response to extracellular signals, such as growth factors and cytokines. The research on MAPKAPK2 has gained importance due to its implications in various diseases, including cancer and inflammatory disorders. Understanding its structural characteristics and biochemical properties through recombinant protein expression is essential for elucidating its mechanism of action. Recombinant MAPKAPK2 enables the study of its enzymatic activity, substrate specificity, and interactions with other cellular proteins. This research can also facilitate the development of target-specific inhibitors, contributing to new therapeutic strategies. Additionally, investigating MAPKAPK2's role in signaling networks enhances our understanding of cellular communication and the regulation of physiological processes. Overall, the study of recombinant MAPKAPK2 represents a significant area of research with potential implications in both basic biology and translational medicine.
