Analytical Data
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基因名
HLA-DRA1*01:01&HLA-DRB1*04:01 Monomer
- Application
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别名
MHCDRa; HLADRa; Major Histocompatibility Complex Class II DR Alpha
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种属
Bovine
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
NM_001012677.1
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表达区间
Lys26~Asn216
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分子量
32kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of HLA-DRA1*01:01 and HLA-DRB1*04:01 monomer recombinant proteins is rooted in the understanding of human immune response, particularly in relation to autoimmune diseases, transplant rejection, and infectious diseases. HLA (Human Leukocyte Antigen) molecules play a crucial role in the presentation of peptide antigens to T cells, influencing adaptive immune responses. HLA-DRB1*04:01 is associated with several autoimmune conditions, such as rheumatoid arthritis and multiple sclerosis, making it a significant target for research. By generating monomeric forms of these HLA class II proteins, researchers aim to study their structural dynamics, binding affinities, and interactions with various peptides. This approach helps elucidate the molecular mechanisms that underlie antigen presentation and T cell activation. Furthermore, these recombinant proteins can facilitate the development of diagnostic tools and therapeutic strategies aimed at modulating immune responses in disease contexts. Understanding the precise mechanisms of HLA-DR interactions not only advances immunological research but also has the potential to improve clinical outcomes in transplantation and autoimmune disease management.
