Analytical Data
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Gene name
NUAK1
- Application
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60285-1
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Expression Region
E2-N661
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Protein Length
Full Length of Isoform-1
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NUAK1 (Nuclear-Akt interacting protein 1) is a serine/threonine kinase that plays a crucial role in various cellular processes, including metabolism, cell proliferation, and cytoskeletal dynamics. As a member of the AMP-activated protein kinase (AMPK) family, NUAK1 is activated under energy-depleted conditions and contributes to cellular adaptation to stress. Aberrant NUAK1 expression has been linked to numerous cancers and metabolic disorders, making it a potential therapeutic target. Research into NUAK1 recombinant proteins has gained momentum as scientists strive to elucidate its function and regulatory mechanisms within the cellular context. By studying NUAK1's interaction with other proteins and its influence on signaling pathways, researchers hope to uncover its role in disease progression and identify novel strategies for intervention. The development of recombinant NUAK1 proteins is essential for in vitro studies, as it allows for detailed biochemical and biophysical characterization, offering insights into its enzymatic activity and substrate specificity. Understanding NUAK1's function in health and disease can pave the way for innovative therapeutic approaches aimed at modulating its activity, thereby providing potential benefits in cancer treatment and metabolic disorder management.
