Analytical Data
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基因名
RPS6KA6
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简介
RSK4 (ribosomal S6 kinase 4) is a serine/threonine protein kinase that is constitutively active and does not require the presence of growth factors to function. It is involved in cell signaling pathways related to cell growth arrest, especially those mediated by p53/TP53 proteins. RPS6KA6 Protein, Human (sf9, GST) is the recombinant human-derived RPS6KA6, expressed by Sf9 insect cells , with GST labeled tag. ,
- Application
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种属
Human
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表达系统
Baculovirus
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标签
GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UK32
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表达区间
M1-L745
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPS6KA6, also known as ribosomal protein S6 kinase A6, is part of the RSK family of serine/threonine kinases, which are critical in various cellular processes, including cell growth, survival, and differentiation. This kinase is involved in the signaling pathways mediated by growth factors and hormones, particularly the mitogen-activated protein kinase (MAPK) pathway. Research has shown that RPS6KA6 plays a pivotal role in the regulation of cell cycle progression and apoptosis, making it a significant player in cancer biology and metabolic disorders. Its aberrant expression has been associated with various tumors, highlighting its potential as a therapeutic target. The recombinant expression and characterization of RPS6KA6 are crucial for understanding its structure-function relationship and elucidating its role in cellular signaling networks. By generating recombinant RPS6KA6, researchers can investigate its kinase activity, substrate specificity, and interactions with other signaling molecules. This research not only advances our fundamental understanding of RPS6KA6’s function but may also provide insights into developing targeted therapies for cancers and other diseases where RPS6KA6 is implicated. Furthermore, understanding how RPS6KA6 is regulated and functions under pathological conditions could lead to novel biomarkers or treatments, emphasizing the importance of this protein in both basic and clinical research.
