Analytical Data
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Gene name
RPS6KA6
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简介
RSK4 (ribosomal S6 kinase 4) is a serine/threonine protein kinase that is constitutively active and does not require the presence of growth factors to function. It is involved in cell signaling pathways related to cell growth arrest, especially those mediated by p53/TP53 proteins. RPS6KA6 Protein, Human (sf9, GST) is the recombinant human-derived RPS6KA6, expressed by Sf9 insect cells , with GST labeled tag. ,
- Application
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Species
Human
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Source
Baculovirus
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Tag
GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UK32
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Expression Region
M1-L745
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RPS6KA6, also known as ribosomal protein S6 kinase A6, is part of the RSK family of serine/threonine kinases, which are critical in various cellular processes, including cell growth, survival, and differentiation. This kinase is involved in the signaling pathways mediated by growth factors and hormones, particularly the mitogen-activated protein kinase (MAPK) pathway. Research has shown that RPS6KA6 plays a pivotal role in the regulation of cell cycle progression and apoptosis, making it a significant player in cancer biology and metabolic disorders. Its aberrant expression has been associated with various tumors, highlighting its potential as a therapeutic target. The recombinant expression and characterization of RPS6KA6 are crucial for understanding its structure-function relationship and elucidating its role in cellular signaling networks. By generating recombinant RPS6KA6, researchers can investigate its kinase activity, substrate specificity, and interactions with other signaling molecules. This research not only advances our fundamental understanding of RPS6KA6’s function but may also provide insights into developing targeted therapies for cancers and other diseases where RPS6KA6 is implicated. Furthermore, understanding how RPS6KA6 is regulated and functions under pathological conditions could lead to novel biomarkers or treatments, emphasizing the importance of this protein in both basic and clinical research.
