Analytical Data
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基因名
ELAVL4
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简介
ELAVL4 protein is a broad RNA-binding factor that post-transcriptionally regulates mRNAs such as GAP43, VEGF, FOS, CDKN1A, and ACHE, stabilizing and protecting them from decay by binding to ARE sequences. It reduces mRNA deadenylation and enhances mRNA binding affinity by interacting with the Poly(A) tail. ELAVL4 Protein, Human (His-SUMO) is the recombinant human-derived ELAVL4 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-10*His;N-SUMO;C-Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P26378-1
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表达区间
M1-S380
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氨基酸序列
MVMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS
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蛋白长度
Full Length of Isoform-1
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分子量
61.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELAVL4, also known as HuD, is a member of the ELAV (embryonic lethal abnormal vision) family of RNA-binding proteins, which play crucial roles in post-transcriptional regulation of gene expression. ELAVL4 is particularly important in the nervous system, where it is involved in the stabilization and transport of mRNAs coding for proteins critical for neuronal development and function. Dysregulation of ELAVL4 has been implicated in various neurological disorders, making it a significant focus of research. The recombinant expression of ELAVL4 allows for detailed studies on its biochemical properties, interaction with target mRNAs, and functional implications in cellular processes. Researchers utilize recombinant ELAVL4 proteins to investigate their role in neurogenesis, synaptic plasticity, and potentially in disease mechanisms associated with neurological disorders such as schizophrenia and neurodegeneration. Furthermore, ELAVL4 may serve as a therapeutic target or biomarker, as understanding its functional dynamics could lead to novel strategies for intervention in related diseases. The study of recombinant ELAVL4 also enhances our understanding of RNA-binding protein families and their broader implications in cellular identity and stress responses. Through these investigations, scientists aim to elucidate the multifaceted roles of ELAVL4 in neuronal biology and its potential contributions to therapeutic advancements in treating neurological conditions.
