Analytical Data
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基因名
Neuregulin-2/NRG2
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简介
Neuregulin-2/NRG2 protein serves as a direct ligand for the ERBB3 and ERBB4 tyrosine kinase receptors, initiating ligand-stimulated tyrosine phosphorylation and activation of these receptors. At the same time, NRG2 simultaneously recruits ERBB1 and ERBB2 coreceptors, possibly promoting heterodimerization with the EGF receptor. Neuregulin-2/NRG2 Protein, Human (HEK293, His) is the recombinant human-derived Neuregulin-2/NRG2 protein, expressed by HEK293 , with C-His labeled tag.
- Application
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别名
Pro-neuregulin-2; Pro-NRG2; Neuregulin-2; DON-1; NTAK; NRG-2
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14511
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表达区间
C112-K404
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蛋白长度
Partial
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
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Protein Description
Neuregulin-2 (NRG2), a member of the neuregulin family, plays a crucial role in the development and functioning of the nervous system and various other tissues. It is known for its involvement in neuronal signaling, as well as its role in the regulation of synaptic plasticity and neurotransmitter release. NRG2 exerts its effects through interactions with erbB receptors, particularly erbB4, influencing processes such as myelination and synaptic modulation. Research has highlighted the potential implications of NRG2 in neurodevelopmental disorders, including schizophrenia and autism spectrum disorders, where altered neuregulin signaling may contribute to disease pathology. The recombinant expression of NRG2 has become essential for elucidating its biological functions and creating therapeutic avenues. Additionally, NRG2's role in cardiovascular and cancer biology underscores its versatility beyond neural contexts. As the development of recombinant protein technologies has advanced, generating and characterizing NRG2 as a recombinant protein offers opportunities for both basic research and the exploration of therapeutic interventions targeting neuregulin signaling pathways. Understanding NRG2's structure-function relationship through recombinant studies can pave the way for drug development and therapeutic applications in conditions associated with NRG2 dysregulation.
