Ipodix Biotech: Small Molecule Antibody Service
Small molecule antibodies (targeting low-MW compounds like drugs, hormones, and toxins) are critical for in vitro diagnostics, drug monitoring, and food safety testing. Ipodix Biotech offers end-to-end services from antigen design to antibody development using hybridoma technology, phage display libraries, and recombinant platforms, delivering highly sensitive and specific custom antibodies.
Technical Advantages
Ipodix overcomes traditional challenges through optimized immunization and screening strategies:
● Hapten design: Enhances immunogenicity via chemical conjugation (carboxyl/amine modification) to carrier proteins (BSA, KLH).
● High-efficiency screening: Competitive ELISA and SPR to minimize cross-reactivity.
● Diverse platforms: Supports mouse/rabbit polyclonal, monoclonal, and nanobody (VHH) development.
● Flexible labeling: Provides biotin, fluorescein, or enzyme (HRP/ALP) conjugates for ELISA, test strips, or biosensors.
Workflow & Timelines
| Hapten Design & Synthesis | 2–3 weeks | Conjugation validation report, immunogenicity assessment. |
| Animal Immunization & Titer Testing | 6–8 weeks | Serum titer data, polyclonal samples (optional). |
| Hybridoma Generation or Phage Screening | 8–10 weeks | Positive monoclonal cell lines/phage clones. |
| Antibody Production & Purification | 2–3 weeks | Purified antibody (1–10 mg), labeled products (optional). |
Quality Control
Ipodix ensures antibody performance through rigorous testing:
● Sensitivity: IC50 ≤1 nM, LOD as low as 0.1 ng/mL.
● Specificity: ≤5% cross-reactivity with structural analogs.
● Stability: ≤10% activity loss after 6 months at 4°C; lyophilized formats for ambient shipping.
● Batch consistency: ≤15% titer variation between batches.
Service Highlights
Challenging Target Solutions
a. Optimized conjugation strategies for molecules <500 Da (e.g., vitamins, amino acid derivatives).
b. Peptide-mimetic epitope technology to enhance immunogenicity of ultra-small molecules.Rapid Development
a. Pre-immune model libraries reduce timelines by 30%; off-the-shelf anti-kanamycin/digoxin antibodies.
b. Phage display platform for animal-free antibody development (8–12 weeks).Custom Labeling
a. Gold-labeled antibodies (20/40 nm particles) for lateral flow test strips.
b. Fluorescent tags (FITC, Cy5) for microfluidic chips or flow cytometry.
Collaboration Process
Requirement Submission: Provide molecular structure, application, and sample type.
Protocol Design: Antigen strategy and development plan within 72 hours.
Immunization & Screening: Regular updates on titer data and candidate antibodies.
Delivery & Validation: Antibody samples with performance reports.
Scale-Up: Milligram to gram-scale production (≥95% purity).
Why Choose Ipodix?
● Proven Expertise: 800+ small molecule antibody projects (pesticides, pharmaceuticals, environmental toxins).
● Comprehensive Solutions: Polyclonal, monoclonal, and nanobodies for diverse applications.
● Cost-Effective: 20–30% lower pricing than market average.
● Global Compliance: Supports FDA/CE certification documentation.
Power Your Small Molecule Detection with Precision!
Contact the Ipodix team via our website or hotline to discuss your project.
