Analytical Data
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基因名
MARCH2
- Application
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别名
Membrane-associated RING finger protein 2 Membrane-associated RING-CH protein II
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P0N8
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表达区间
1-246aa
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分子量
43 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MARCH2 (Membrane-Associated RING-CH2) is an E3 ubiquitin ligase that plays a critical role in regulating the stability and trafficking of various membrane proteins, influencing diverse biological processes such as immune responses and cellular signaling. Research into MARCH2 has gained attention due to its involvement in modulating the expression of major histocompatibility complex (MHC) molecules, which are essential for antigen presentation and immune system functioning. The understanding of MARCH2's functions is crucial in contexts such as viral evasion, where some pathogens hijack MARCH2 to downregulate MHC molecules and escape immune detection. Additionally, emerging studies point towards MARCH2's potential role in various diseases, including autoimmune disorders and cancer, where altered expression of MARCH2 correlates with disease prognosis. Researchers are increasingly focused on characterizing the structure and function of MARCH2, as well as its interactions with substrates and other cellular components. The elucidation of MARCH2's mechanisms may pave the way for novel therapeutic strategies, particularly in enhancing immune responses against tumors and infections. Overall, the investigation into MARCH2 and its associated pathways is a significant area of research, providing insights into fundamental cellular processes and potential clinical applications.
