Analytical Data
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基因名
CCT2
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简介
The CCT2 protein is an important component of the chaperone-containing T complex (TRiC), a molecular chaperone that assists in protein folding through ATP hydrolysis. CCT2 Protein, Human (His-SUMO) is the recombinant human-derived CCT2 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P78371-1
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表达区间
A2-C535
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氨基酸序列
ASLSLAPVNIFKAGADEERAETARLTSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDASLMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIIAGWREATKAAREALLSSAVDHGSDEVKFRQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHIIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDSRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESYAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGNTTAGLDMREGTIGDMAILGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC
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蛋白长度
Full Length of Isoform-1 Mature Protein
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分子量
66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCT2, or Chaperonin Containing TCP1 Subunit 2, is a key member of the CCT (Chaperonin Containing TCP1) complex, which plays a critical role in the proper folding of cytosolic proteins, particularly those involved in the assembly of multi-subunit proteins. The significance of CCT2 in cellular processes has drawn attention due to its involvement in critical functions such as protein homeostasis, cellular stress responses, and regulation of cell growth. Abnormalities in CCT2 have been implicated in various diseases, including cancer and neurodegenerative disorders, making it a potential target for therapeutic interventions. Research on CCT2 recombinant proteins involves elucidating its structure, function, and interactions within the cellular environment, as well as its role in pathology. Understanding the biochemical properties of CCT2, including its interaction with client proteins and other chaperones, can provide insights into molecular mechanisms of disease and aid in the development of novel therapeutic strategies. Moreover, the production of recombinant CCT2 proteins in model systems allows for comprehensive studies on its folding mechanisms and functional dynamics, ultimately contributing to a greater understanding of protein misfolding diseases. Overall, research on CCT2 and its recombinant forms is vital for advancing the knowledge of protein biology and for the potential development of therapeutic approaches targeting its associated pathways.
