Analytical Data
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Gene name
TGFBR2/TGF-beta RII
- Application
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Alternative Names
TGFR-2; TGF-beta type II receptor; TGF-beta receptor type 2; TbetaR-II
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Species
Mouse
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Source
HEK293
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Tag
C-Fc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q62312-2
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Expression Region
I24-D159
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Protein Length
Partial
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Molecular Weight
55-65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Transforming growth factor-beta receptor II (TGFBR2) is a crucial component in the TGF-beta signaling pathway, which plays a significant role in various cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of TGFBR2 has been implicated in multiple diseases, notably cancer and fibrosis, highlighting its importance as a therapeutic target. The study of recombinant TGFBR2 proteins has gained momentum due to their potential applications in drug development and biological research. By producing and characterizing these proteins, researchers aim to understand their structure-function relationships and develop strategies to modulate TGF-beta signaling for clinical benefit. Recombinant TGFBR2 can be used to investigate ligand-receptor interactions, elucidate downstream signaling mechanisms, and screen for small molecule inhibitors. Additionally, given the receptor's role in immune regulation, recombinant forms offer promise for developing novel immunotherapies. Overall, the research surrounding TGFBR2/TGF-beta RII recombinant proteins is pivotal for unraveling the complexities of TGF-beta signaling and exploring their potential in treating diseases associated with its dysregulation.
