Analytical Data
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基因名
PELI2
- Application
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别名
PELI2; E3 ubiquitin-protein ligase pellino homolog 2; Pellino-2; RING-type E3 ubiquitin transferase pellino homolog 2
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9HAT8
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表达区间
F2-D420
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PELI2, or Pellino E3 Ubiquitin Ligase 2, is a member of the Pellino family of E3 ubiquitin ligases that play a crucial role in the regulation of immune responses and cellular signaling pathways. Research on PELI2 has gained momentum due to its involvement in various biological processes, including inflammation, apoptosis, and cell proliferation. Given its pivotal role in the immune system, dysregulation of PELI2 has been linked to autoimmune diseases, cancers, and infectious diseases. The protein mediates the ubiquitination of target proteins, thereby influencing their stability, localization, and function. PELI2 has been shown to interact with key signaling molecules in pathways such as Toll-like receptor (TLR) signaling, which is essential for pathogen recognition and the subsequent activation of immune responses. Understanding the structure and function of PELI2, along with its interacting partners, may provide insights into its role as a potential therapeutic target. Researchers have been focusing on the development of recombinant PELI2 proteins to study its biochemical properties and to evaluate its regulatory mechanisms in immune signaling. Overall, the study of PELI2 not only enhances our understanding of immune regulation but also holds promise for novel therapeutic approaches in treating diseases characterized by immune dysregulation.
