Analytical Data
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Gene name
Apolipoprotein C-III/APOC3
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简介
Apolipoprotein C-III (APOC3) is a component of VLDL and HDL and plays a crucial role in triglyceride homeostasis. Intracellularly, it facilitates the assembly and secretion of VLDL1 for lipid transport. Apolipoprotein C-III/APOC3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived Apolipoprotein C-III/APOC3 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
- Application
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Alternative Names
Apoc3Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3
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Species
Mouse
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Source
E. coli
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Tag
N-6*His;N-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P33622
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Expression Region
E21-S99
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Protein Length
Full Length of Mature Protein
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Molecular Weight
22 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Apolipoprotein C-III (ApoC-III) is a key component of lipoproteins and plays a crucial role in lipid metabolism and cardiovascular health. It is primarily synthesized in the liver and intestines and is known to inhibit lipoprotein lipase, thereby affecting triglyceride clearance from the bloodstream. Elevated levels of ApoC-III have been linked to an increased risk of dyslipidemia and cardiovascular diseases. As such, studying the biochemical properties and functions of ApoC-III is vital for understanding its role in lipid disorders and developing therapeutic strategies. Recombinant ApoC-III protein has become a valuable tool in research, allowing scientists to investigate its physiological effects and interactions with other lipoproteins in a controlled environment. By producing this protein through recombinant DNA technology, researchers can examine its effects on lipid metabolism, explore potential inhibitors, and assess its implications in diseases related to cholesterol and triglyceride metabolism. Consequently, the understanding of ApoC-III through recombinant protein studies may not only elucidate its biological functions but also contribute to innovative approaches in the treatment of lipid-related diseases.
