Analytical Data
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Gene name
TGFBR1/ALK-5
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简介
TGFBR1/ALK-5 proteins cooperate with TGFBR2 to form dedicated receptors for TGFB1, TGFB2, and TGFB3, transmitting signals and coordinating different physiological and pathological processes. It induces cell cycle arrest, modulates mesenchymal cell dynamics, contributes to wound healing, and affects immunosuppression and carcinogenesis. TGFBR1/ALK-5 Protein, Human (sf9, His-GST) is the recombinant human-derived TGFBR1/ALK-5 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
- Application
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Alternative Names
TGF-beta receptor type-1; ALK-5; SKR4; TbetaR-I; AAT5
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Species
Human
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Source
Baculovirus
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Tag
N-His;N-GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36897
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Expression Region
T200-M503
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Protein Length
Partial
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Molecular Weight
57 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGFBR1 (Transforming Growth Factor Beta Receptor 1) and ALK-5 (Activin Like Kinase 5) are critical components of the TGF-β signaling pathway, which plays a vital role in numerous cellular processes, including proliferation, differentiation, and apoptosis. Dysregulation of this pathway is implicated in various diseases, including fibrosis, cancer, and cardiovascular disorders. The study of TGFBR1/ALK-5 recombinant proteins aims to elucidate the molecular mechanisms of TGF-β signaling and its downstream effects. Researchers are particularly interested in the receptor's structure, function, and interactions with ligands, as well as how mutations or aberrant expression may contribute to pathological conditions. Utilizing recombinant protein technology enables the production of these receptors in controlled laboratory settings, facilitating functional assays, structural studies, and drug discovery efforts. By understanding the exact role of TGFBR1/ALK-5 in cellular processes, scientists hope to identify potential therapeutic targets for diseases associated with TGF-β signaling dysregulation, ultimately leading to the development of innovative treatments that could ameliorate or even reverse the effects of these diseases.
