Analytical Data
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Gene name
MARK4
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简介
MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96L34
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Expression Region
N44-K370
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MARK4 protein, part of the Microtubule Affinity Regulating Kinases (MARK) family, plays a crucial role in cellular processes such as microtubule dynamics, cell signaling, and cell cycle regulation. Research into MARK4 has gained momentum due to its involvement in various biological functions and potential implications in diseases, particularly cancer. MARK4 regulates the stability and organization of microtubules through its phosphorylation activity, influencing cell shape, movement, and division. Abnormalities in MARK4 expression or function have been linked to tumorigenesis and other pathologies, making it a significant focus of cancer research. Understanding the molecular mechanisms governing MARK4 activity could unveil novel therapeutic targets for cancers characterized by altered microtubule dynamics. Moreover, MARK4 is implicated in the regulation of neuronal processes, emphasizing its relevance in neurobiology. Investigating MARK4’s structure, enzymatic properties, and regulatory pathways can provide insights into its role in both normal physiology and disease states, paving the way for innovative approaches to manipulate its activity for therapeutic benefits.
