Analytical Data
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基因名
MARK4
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简介
MARK4 is a key serine/threonine protein kinase with crucial effects on cellular processes. It phosphorylates microtubule-associated proteins (MAPT/TAU, MAP2, MAP4) and reorganizes the microtubule network. MARK4 Protein, Human (His) is the recombinant human-derived MARK4 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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别名
MARK4; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase-like 1
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种属
Human
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表达系统
E. coli
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标签
N-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96L34
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表达区间
N44-K370
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The MARK4 protein, part of the Microtubule Affinity Regulating Kinases (MARK) family, plays a crucial role in cellular processes such as microtubule dynamics, cell signaling, and cell cycle regulation. Research into MARK4 has gained momentum due to its involvement in various biological functions and potential implications in diseases, particularly cancer. MARK4 regulates the stability and organization of microtubules through its phosphorylation activity, influencing cell shape, movement, and division. Abnormalities in MARK4 expression or function have been linked to tumorigenesis and other pathologies, making it a significant focus of cancer research. Understanding the molecular mechanisms governing MARK4 activity could unveil novel therapeutic targets for cancers characterized by altered microtubule dynamics. Moreover, MARK4 is implicated in the regulation of neuronal processes, emphasizing its relevance in neurobiology. Investigating MARK4’s structure, enzymatic properties, and regulatory pathways can provide insights into its role in both normal physiology and disease states, paving the way for innovative approaches to manipulate its activity for therapeutic benefits.
