Analytical Data
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Gene name
IRF3
- Application
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Alternative Names
Short name:IRF-3
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Species
Mouse
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Source
Yeast
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Tag
N- His & C- Myc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P70671
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Expression Region
1-419aa
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Molecular Weight
50.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
IRF3 (Interferon Regulatory Factor 3) is a crucial transcription factor in the innate immune response, primarily involved in the regulation of type I interferon and various pro-inflammatory cytokines during viral infection and other immune challenges. The activation of IRF3 is primarily triggered by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs), which detect viral components. Upon activation, IRF3 undergoes phosphorylation, dimerization, and subsequent nuclear translocation, where it initiates the transcription of interferon-stimulating genes (ISGs). The significance of IRF3 has led to extensive research into its structure, function, and regulatory mechanisms. Recombinant IRF3 proteins have been utilized in various studies to elucidate its role in immune signaling pathways and to explore potential therapeutic interventions for viral infections, autoimmune diseases, and cancer. By producing and studying these recombinant proteins, researchers aim to better understand the molecular interactions and dynamics of the immune response, which could ultimately aid in the development of new antiviral therapies and immune-modulating treatments. As the immune system's first line of defense, understanding the intricacies of IRF3 and its pathways holds promise for enhancing therapeutic strategies in infectious diseases and beyond.
