Analytical Data
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基因名
IRF3
- Application
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P70671
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表达区间
Met1~Asp406
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分子量
44kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IRF3 (Interferon Regulatory Factor 3) is a crucial transcription factor in the innate immune response, primarily involved in the regulation of type I interferon and various pro-inflammatory cytokines during viral infection and other immune challenges. The activation of IRF3 is primarily triggered by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs), which detect viral components. Upon activation, IRF3 undergoes phosphorylation, dimerization, and subsequent nuclear translocation, where it initiates the transcription of interferon-stimulating genes (ISGs). The significance of IRF3 has led to extensive research into its structure, function, and regulatory mechanisms. Recombinant IRF3 proteins have been utilized in various studies to elucidate its role in immune signaling pathways and to explore potential therapeutic interventions for viral infections, autoimmune diseases, and cancer. By producing and studying these recombinant proteins, researchers aim to better understand the molecular interactions and dynamics of the immune response, which could ultimately aid in the development of new antiviral therapies and immune-modulating treatments. As the immune system's first line of defense, understanding the intricacies of IRF3 and its pathways holds promise for enhancing therapeutic strategies in infectious diseases and beyond.
