Analytical Data
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基因名
PNCK
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简介
The PNCK protein is a calcium/calmodulin-dependent protein kinase and a key component of the calcium-triggered signaling cascade. In vitro, PNCK exhibits the ability to phosphorylate CREB1 and SYN1/synapsin I, emphasizing its involvement in regulating cellular processes associated with these substrates. PNCK Protein, Human (sf9, His, GST) is the recombinant human-derived PNCK protein, expressed by sf9 insect cells , with N-8*His, N-GST labeled tag.
- Application
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别名
PNCK; Calcium/calmodulin-dependent protein kinase type 1B; CaM kinase I beta; CaM kinase IB; CaM-KI beta; CaMKI-beta; Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
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种属
Human
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表达系统
Baculovirus
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标签
N-8*His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6P2M8
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表达区间
L2-W343
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蛋白长度
Partial
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PNCK (p41Nop56/Nop58 complex) is a member of the cyclin-dependent kinase (CDK) family, playing a significant role in cell cycle regulation and various cellular processes. Its importance has been underscored in recent years due to its potential involvement in oncogenesis, as aberrant expression of PNCK has been linked to several types of cancer. The study of PNCK recombinant proteins is critical for understanding its biochemical properties, regulatory mechanisms, and interactions with other cellular proteins. Recombinant PNCK can be utilized in various experimental settings, such as crystallography and binding assays, to elucidate its structure-function relationship. Investigating PNCK through recombinant techniques also enables the development of specific inhibitors that could serve as therapeutic agents. Furthermore, the exploration of PNCK's role in cellular pathways and its interaction with CDK inhibitors might reveal novel insights into cancer biology and identify potential biomarkers for tumor progression. Overall, the research on PNCK recombinant proteins can pave the way for innovative approaches to cancer treatment, emphasizing the need for continued exploration in this promising field.
