Analytical Data
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Gene name
ACVR1
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简介
Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation[1]. ACVR1 Protein, Rat (HEK293, hFc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 103 amino acids (M21-E123).
- Application
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Biological Activity
Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 is used at 0.25 μg/mL, the concentration of Recombinant Rat ACVR1. The ED50 for this effect is 4.39 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 is used at 0.25 μg/mL, the concentration of Recombinant Rat ACVR1. The ED50 for this effect is 4.39 μg/mL.
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Alternative Names
Activin receptor type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1
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Species
Rat
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P80201
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Expression Region
M21-E123
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Protein Length
Extracellular Domain
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Molecular Weight
43-48 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1, also known as Activin A receptor type I, plays a critical role in the bone morphogenetic protein (BMP) signaling pathway, which is pivotal for various cellular processes including bone development and repair. Mutations in the ACVR1 gene are implicated in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterized by abnormal bone formation in soft tissues. This has heightened interest in ACVR1 as a potential therapeutic target for preventing unwanted ossification. Research into ACVR1 recombinant proteins has focused on understanding its structure, function, and interaction with various ligands, aiming to elucidate the mechanisms governing its dysregulation in diseases like FOP. By developing and characterizing ACVR1 recombinant proteins, scientists seek to discover novel interventions that could inhibit its aberrant signaling pathways, thereby offering hope for effective treatments. Furthermore, studying these recombinant proteins enhances our understanding of the BMP pathway, potentially leading to broader applications in regenerative medicine and orthopedics. Thus, the exploration of ACVR1 recombinant proteins holds significant potential for addressing not only FOP but also other conditions associated with abnormal bone growth.
