Analytical Data
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基因名
ACVR1
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简介
Activin A receptor, type I (ACVR1), also known as ALK-2, is a bone morphogenetic protein (BMP) type I receptor. ACVR1 is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation[1]. ACVR1 Protein, Rat (HEK293, hFc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 103 amino acids (M21-E123).
- Application
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生物活性
Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 is used at 0.25 μg/mL, the concentration of Recombinant Rat ACVR1. The ED50 for this effect is 4.39 μg/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human BMP-6 is used at 0.25 μg/mL, the concentration of Recombinant Rat ACVR1. The ED50 for this effect is 4.39 μg/mL.
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别名
Activin receptor type-1; ACTR-I; SKR1; TSR-I; TSK-7L; Acvrlk2; Tgfb1
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种属
Rat
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 95% as determined by SDS-PAGE.
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蛋白编号
P80201
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表达区间
M21-E123
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蛋白长度
Extracellular Domain
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分子量
43-48 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACVR1, also known as Activin A receptor type I, plays a critical role in the bone morphogenetic protein (BMP) signaling pathway, which is pivotal for various cellular processes including bone development and repair. Mutations in the ACVR1 gene are implicated in fibrodysplasia ossificans progressiva (FOP), a rare genetic disorder characterized by abnormal bone formation in soft tissues. This has heightened interest in ACVR1 as a potential therapeutic target for preventing unwanted ossification. Research into ACVR1 recombinant proteins has focused on understanding its structure, function, and interaction with various ligands, aiming to elucidate the mechanisms governing its dysregulation in diseases like FOP. By developing and characterizing ACVR1 recombinant proteins, scientists seek to discover novel interventions that could inhibit its aberrant signaling pathways, thereby offering hope for effective treatments. Furthermore, studying these recombinant proteins enhances our understanding of the BMP pathway, potentially leading to broader applications in regenerative medicine and orthopedics. Thus, the exploration of ACVR1 recombinant proteins holds significant potential for addressing not only FOP but also other conditions associated with abnormal bone growth.
