Analytical Data
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Gene name
FES
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简介
FES, a tyrosine-protein kinase, regulates cellular processes, including actin dynamics and cell spreading. It influences FCER1-mediated signaling in mast cells, KIT receptor pathways, and NGF-induced neurite outgrowth. FES contributes to HGF-triggered cell scattering and migration, phosphorylating proteins like BCR and HCLS1/HS1, impacting cellular signaling pathways. FES Protein, Human (His) is the recombinant human-derived FES, expressed by E. coli , with His labeled tag.
- Application
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Alternative Names
Tyrosine-protein kinase Fes/Fps; Proto-oncogene c-Fes; FES; FPS
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Species
Human
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Source
E. coli
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Tag
His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P07332-1
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Expression Region
I448-R822
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Protein Length
Partial
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FES (Feline Sarcoma Viral Oncogene Homolog) is a member of the Tec family of non-receptor tyrosine kinases, which play crucial roles in various cellular processes, including cell survival, proliferation, and differentiation. The research on FES recombinant proteins has gained significance due to their potential involvement in several cancer types, particularly hematological malignancies. FES is often overexpressed in certain tumors, suggesting a link to oncogenesis, making it a potential target for cancer therapy. Furthermore, FES is implicated in immune cell signaling, influencing the function and development of various immune cells, such as mast cells and macrophages. This dual role in both tumorigenesis and immune regulation has prompted researchers to explore FES as a therapeutic target. Constructing recombinant proteins of FES allows for detailed investigation of its structure, function, and interaction with other signaling molecules. By understanding these mechanisms, scientists hope to develop novel strategies for cancer treatment and therapies that can manipulate immune responses. With advancements in biotechnology, the generation of FES recombinant proteins not only aids in basic research but also paves the way for the development of innovative therapeutics aimed at conditions associated with FES dysregulation. The exploration of FES in the context of targeted therapy and personalized medicine underscores the importance of this protein in ongoing cancer research and immune modulation studies.
