Analytical Data
-
基因名
HLA-A*02:01&B2M&HPV(TIHDIILECV) Monomer
- Application
-
别名
HLA-A*0201 & B2M & HPV (TIHDIILECV)
-
种属
Human
-
表达系统
HEK293
-
标签
C-Avi;C-His
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
AAA59606.1 (G25-I308)&P61769
-
表达区间
AAA59606.1 (G25-I308)&P61769 (I21-M119)&TIHDIILECV
-
分子量
40-43 kDa and 12 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of the HLA-A*02:01/B2M/HPV(TIHDIILECV) monomer recombinant protein is situated within the essential context of immunology and cancer research. Human leukocyte antigen (HLA) molecules, particularly HLA-A*02:01, play a pivotal role in the immune system by presenting peptide fragments derived from proteins, including those from human papillomavirus (HPV), to CD8+ T cells. HPV is a well-known etiological agent in cervical cancer and other malignancies, making the understanding of its interaction with HLA molecules critical for vaccine development and immunotherapeutic strategies. The specific peptide TIHDIILECV derived from the HPV-E7 protein has been shown to elicit a robust immune response, particularly in individuals with HLA-A*02:01, which is one of the most common HLA alleles. By developing a monomeric recombinant protein complex of HLA-A*02:01, beta-2-microglobulin (B2M), and the HPV peptide, researchers aim to investigate its structural characteristics and stability, as well as its interactions with T cell receptors. This research may illuminate mechanisms of immune recognition and contribute to the design of targeted immunotherapies that enhance the efficacy of the anti-HPV immune response, potentially leading to improved treatment options for HPV-associated cancers.
