Analytical Data
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基因名
TYRO3/DTK
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简介
TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation.Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules.TYRO3/DTK Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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生物活性
Immobilized Mouse TYRO3 at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse GAS6 protein. The ED50 for this effect is 1.95 μg/mL. Immobilized Mouse TYRO3 at 1 μg/mL (100 μL/well) can bind Biotinylated Mouse GAS6 protein. The ED50 for this effect is 1.95 μg/mL.
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别名
rMuTyrosine-protein kinase receptor TYRO3/DTK, Fc; Tyrosine-protein kinase receptor TYRO3; Etk2; tyro3; TK19-2; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase TIF
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55144
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表达区间
A31-S418
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氨基酸序列
AGLKLMGAPVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRLQAPPAAPFNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTS
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蛋白长度
Extracellular Domain
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分子量
90-120 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TYRO3/DTK is a member of the TAM receptor tyrosine kinase family, which includes AXL and MER. These receptors play crucial roles in various biological processes, including regulation of immune responses, tissue homeostasis, and clearance of apoptotic cells. The study of TYRO3/DTK has gained attention due to its involvement in cancer biology, where it may contribute to tumor progression and resistance to therapies. Dysregulation of TYRO3/DTK signaling has been linked to several malignancies, making it a potential target for therapeutic interventions. Furthermore, the receptor's role in modulating inflammatory responses suggests its importance in autoimmune diseases and other inflammatory conditions. Given these factors, the recombinant protein of TYRO3/DTK presents an opportunity to explore its functional roles in cellular signaling pathways and to develop potential therapeutic strategies for treating various diseases. Recombinant TYRO3/DTK can be used in assays to study its binding interactions, downstream signaling mechanisms, and effects on cell behavior, providing insights into its biological significance and potential as a drug target. Understanding the structural and functional aspects of TYRO3/DTK is essential for elucidating its mechanisms of action and for the development of novel treatments aimed at inhibiting its pathological functions. This research may pave the way for innovative therapeutic approaches that exploit the modulation of TYRO3/DTK signaling in disease management.
