Analytical Data
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Gene name
PIM2
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简介
The PIM2 protein is a proto-oncogene with serine/threonine kinase activity that critically promotes cell survival and proliferation through multiple mechanisms. It enhances MYC stability and transcriptional activity, explaining the synergistic effect in tumorigenesis. PIM2 Protein, Human is the recombinant human-derived PIM2 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
PIM2; Serine/threonine-protein kinase pim-2; Pim-2h
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P1W9
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Expression Region
M1-P311
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PIM2 (Proviral Integration site for Moloney murine leukemia virus 2) is a serine/threonine kinase that plays a pivotal role in various cellular processes, including cell survival, proliferation, and differentiation. As a member of the PIM kinase family, PIM2 is known to be overexpressed in several types of cancer, highlighting its potential as a therapeutic target. The study of PIM2 recombinant proteins is crucial for elucidating its biochemical properties, substrate specificity, and interaction with other signaling pathways. By generating and analyzing PIM2 in a recombinant form, researchers can investigate its role in oncogenesis, particularly in the context of lymphoma and leukemia, where its dysregulation contributes to malignancy. Furthermore, understanding PIM2's molecular mechanisms can pave the way for the development of targeted inhibitors that could provide new avenues for cancer treatment. The recombinant expression of PIM2 allows for advanced characterization techniques, such as crystallography and mass spectrometry, to reveal insights into its structure-function relationships. Consequently, studying recombinant PIM2 not only enhances our fundamental understanding of kinase activity but also assists in the identification of novel biomarkers and therapeutic strategies in cancer research.
