Analytical Data
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基因名
PIM2
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简介
The PIM2 protein is a proto-oncogene with serine/threonine kinase activity that critically promotes cell survival and proliferation through multiple mechanisms. It enhances MYC stability and transcriptional activity, explaining the synergistic effect in tumorigenesis. PIM2 Protein, Human is the recombinant human-derived PIM2 protein, expressed by E. coli , with tag free.
- Application
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别名
PIM2; Serine/threonine-protein kinase pim-2; Pim-2h
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9P1W9
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表达区间
M1-P311
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蛋白长度
Full Length
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PIM2 (Proviral Integration site for Moloney murine leukemia virus 2) is a serine/threonine kinase that plays a pivotal role in various cellular processes, including cell survival, proliferation, and differentiation. As a member of the PIM kinase family, PIM2 is known to be overexpressed in several types of cancer, highlighting its potential as a therapeutic target. The study of PIM2 recombinant proteins is crucial for elucidating its biochemical properties, substrate specificity, and interaction with other signaling pathways. By generating and analyzing PIM2 in a recombinant form, researchers can investigate its role in oncogenesis, particularly in the context of lymphoma and leukemia, where its dysregulation contributes to malignancy. Furthermore, understanding PIM2's molecular mechanisms can pave the way for the development of targeted inhibitors that could provide new avenues for cancer treatment. The recombinant expression of PIM2 allows for advanced characterization techniques, such as crystallography and mass spectrometry, to reveal insights into its structure-function relationships. Consequently, studying recombinant PIM2 not only enhances our fundamental understanding of kinase activity but also assists in the identification of novel biomarkers and therapeutic strategies in cancer research.
