Analytical Data
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Gene name
CAMKK1
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简介
The CAMKK1 protein is a calcium/calmodulin-dependent kinase and a key player in calcium-triggered signaling cascades involved in various cellular processes. It phosphorylates multiple members of the CAMK1 family, including CAMK1, CAMK1D, CAMK1G, and CAMK4. CAMKK1 Protein, Human (sf9) is the recombinant human-derived CAMKK1 protein, expressed by sf9 insect cells , with tag free.
- Application
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Species
Human
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Source
Baculovirus
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N5S9
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Expression Region
M1-S505
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CAMKK1 (Calcium/Calmodulin-dependent protein kinase kinase 1) is a crucial enzyme involved in cellular signaling pathways, particularly those regulated by calcium and calmodulin. Its primary role is to activate AMPK (AMP-activated protein kinase) in response to increases in intracellular calcium levels, thereby influencing energy metabolism, cell growth, and proliferation. Research has demonstrated that CAMKK1 is implicated in various physiological and pathological processes, including metabolism, neuroprotection, and cancer progression. The interest in CAMKK1 has surged due to its potential as a therapeutic target for metabolic disorders and tumors. Recombinant CAMKK1 protein has emerged as a valuable tool for studying its enzymatic mechanisms, molecular interactions, and regulatory effects in different cellular contexts. By expressing and purifying CAMKK1 in a recombinant system, researchers can investigate its structure-function relationships and assess the effects of specific modulators or inhibitors on its activity. This understanding may lead to the development of new therapeutic strategies aimed at modulating CAMKK1 activity for various diseases. Hence, studies focused on the characterization and functional analysis of recombinant CAMKK1 protein are vital for unveiling its biological significance and therapeutic potential.
